105 W First Street

105 W First Street

105 West First Street


Turnkey cafe opportunity in the lobby of The 105 by Breakthrough, the new home of CRISPR Therapeutics located along the A Street corridor, a cluster of mixed-use development weaving together the Seaport District, Fort Point and South Boston neighborhoods. The property boasts a public way through the lobby, which connects W Second Street with W First Street and the A Street Park. Just a 5-minute walk from the Broadway T-Station and easily accessible by rideshare, bike or foot.  

This unique partnership offers a talented restaurateur the opportunity to provide a critical food and beverage amenity  to a world-class life sciences tenant while also serving the broader South Boston community.  


  • Status : Opening Spring 2022
  • Client : Breakthrough
  • Neighborhood : South Boston
  • Address : 105 West First Street, Boston, MA
  • Building Type(s) : Office, Retail
  • Available Retail Square Footage : 1,600 SF + Supplemental Storage
  • Desired Use : Cafe